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Pharma & Biotech

SAEC – Human Small Airway Epithelial Cells

Catalog #: CC-2547

 Cryopreserved ampule of Small Airway Epithelial Cells (SAEC) containing ≥500,000 cells. Some lots have been screened for alveolar type 1 and 2.

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Product Overview

Lonza's Human Small Airway Epithelial Cells (SAEC) are isolated from normal human lung tissue the distal portion of the lung in the 1mm bronchiole area. These cells consist of alveolar epithelial cells type 1 and 2 population.

Cryopreserved SAECs or Alveolar Cells are guaranteed through 15 population doublings and stain positive for cytokeratin 19.  SAECs or Alveolar Cells labeled CC-2547S are suitable for air-liquid interface studies and are guaranteed for differentiation marked by cilia formation, mucin production, and TEER levels. Cells from various diseased donors are also available. 

All cells test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased.

Benefits

  • All cells test negative for mycoplasma, bacteria, yeast, and fungi
  • HIV-1, Hepatitis B and Hepatitis C are not detected for all donors and/or cell lots
  • Certificate of Analysis provided for every cell lot

 

Content & Storage

Content

1 x Cryopreserved ampule SAEC containing ≥500,000 cells

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

Co-culture Experiments with Lonza's Small Airway Epithelial Cells and SAGMTM BulletKitTM Media

Data Courtesy of Furukawa, et al. Lonza's SAEC cells were co-cultured with primary normal mammary epithelial cells, breast cancer cell lines MCF-7 and MDA-MB-231 in Lonza's SAGMTM BulletKitTM Growth Media. Breast cancer cell lines showed differences in morphology and proliferation rates in the presence of small airway epithelial cells. The image above shows phase contrast imaging with a fluorescent (red) overlay of MCF-7 cell line. MCF-7 cell lines survived as tight clusters in SAGMTM Media. When co-cultured with Lonza's primary SAECs, MCF-7 cells demonstrated enhanced growth all the while staying clustered.

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