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Pharma & Biotech

DHLF-IPF - Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis

Catalog #: CC-7231

Cryopreserved ampule of Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis (DHLF-IPF) containing ≥ 500,000 cells

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Product Overview

IPF (Idiopathic Pulmonary Fibrosis) is a fatal disease that usually affects adults between the ages of 50-70. The disease is characterized by progressive decline in lung function resulting from scarring of lung tissue.

IPF varies from person to person where in some, fibrosis happens quickly, while the process can be much slower in others. IPF has no cure yet and both geneticand environmental factors are attributed to the development of the disease. Genetics may play a role in causing IPF, and cigarette smoking is the most accepted risk factor in increasing the chances of developing IPF. Recent research has helped doctors understand the disease more closely so they can more quickly diagnose it than in the past. Efforts are still underway in the research community to understand the pathways of disease progression and subsequently develop cures for IPF. IPF was once thought to be a chronic inflammatory process but recent evidence suggests that the abnormal activation of alveolar epithelial cells (AECs) induce over-activation of fibrotic response. The fibroblast and myofibroblast foci secrete excessive amounts of collagens, leading to scarringand destruction of the lung architecture. The mechanisms that link IPF with ageing and aberrant epithelial activation are unknown.

To understand the progression of IPF disease, Lonza offers cryopreserved lung fibroblasts isolated from donors diagnosed with IPF. Cryopreserved IPF fibroblasts are shipped at passage 2 and stain negative for von Willebrand factor VIII, cytokeratins 14, 18 and 19, and alpha smooth muscle actin. All cells test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased.

Relevant Downloads (Lonza's Normal Human Lung Fibroblasts for IPF Research):

 

Benefits

  • Gene expression pathways   
  • Phenotypic changes to compounds   
  • Transfect diseased cells   
  • Co-culture with immune cells   
  • Airway remodeling studies   
  • Cellular interaction

Content & Storage

Content

1 x Cryopreserved ampule of DHLF-IPF containing ≥500,000 cells

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

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