The kidney is a key organ of the urinary system, which plays a pivotal role in many physiological processes such as the maintenance of homeostasis, the excretion of nitrogen waste and the secretion of endocrine factors. Nephron -- the structural and functional unit of kidney -- is a highly complex organ comprised of convoluted tubules, the cortical collecting ducts, the calyxes, and the renal pelvis. The epithelial cells located in the tubules and ducts differ in their physiology and morphology and exert critical functions in the kidney1.
Renal cells in the proximal tubule play physiological roles in the re-absorption of small molecular weight proteins, peptides and glucose via receptors present on the villi of their luminal surface2. This localization and biological role exposes these cells to numerous challenging stimuli in the event of any up-stream pathology, with excessive protein, glucose, toxins, advanced glycation end products (AGEs) and bacterial products all being able to perturb normal renal epithelial cell physiology.3
In vitro renal epithelial cell culture systems are considered to be the most valuable tool for studying renal physiology, nephrotoxicity studies, drug transporter studies, disease models, renal transplantation models, cancer models and more. Refer to our select references highlighting different applications of Lonza's renal cells including but not limited to ADME-Tox research.