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Pharma & Biotech

DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Female

Catalog #: HUCS10PF
Pooled 10-donor female only human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities. Ideal for drug metabolite identification, characterization, and turnover kinetics.
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Product Overview

 

A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm, we are able to predict yield, viability, and functional phenotype representing the average human populations.  The DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Female, is a single gender, 10 donor pool designed to function like the average female liver.  Each batch is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.

With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs. 

DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Female hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays in a single gender pool.  These suspension qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.

 

Benefits

  • Targeted pooling method for predictable metabolism 
  • Precharacterized for 9 CYPs and 4 drug transporters
  • High viability and yields
  • Lot sizes < 2000 are possible

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

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Human Hepatocyte Inventory

Human

Inventory

View donor information and select characteristics of currently available human hepatocyte lots. Table includes single donor and pooled donor lots in either suspension or plateable formats

DonorPlexTM Pooled Donor Suspension Hepatocytes

Technical Note

Read our new tech note to learn more about DonorPlexTM Hepatocytes, our pooled donor hepatocytes, and a proprietary prediction algorithm,  go beyond your expectations for a robust and consistent pooled donor hepatocyte product.

Custom DonorPlexTM Human Hepatocytes Request

Form

Start your path towards obtaining DonorPlexTM Hepatocytes customized for your specific needs.

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