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Pharma & Biotech

DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male

Catalog #: HUCS10PM

Pooled 10-donor, male human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities. Ideal for drug metabolite identification, characterization, and turnover kinetics.

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Product Overview

A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm we are able to predict yield, viability, and functional phenotype representing the average human populations.  The DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male, is a single gender, 10 donor pool designed to function like the average male liver hepatocyte.  Each batch of pooled 10-donor, male human hepatocytes is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.

 

With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs. 

DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays in a single gender pool.  The Suspension Qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.

 

Benefits

  • Targeted pooling method for predictable metabolism 
  • Precharacterized for 9 CYPs and 4 drug transporters
  • High viability and yields
  • Lot sizes < 2000 are possible

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

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Introducing...DonorPlexTM Pooled Donor Human Hepatocytes

Product Info

Advancing pooled-donor hepatocytes to the next level of consistency, robustness, and customizability

Custom DonorPlexTM Human Hepatocytes Request

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Start your path towards obtaining DonorPlexTM Hepatocytes customized for your specific needs.

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