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Confidence for Adopting the rFC Method in Your Lab

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Article overview

Comparing endotoxin testing results of modern recombinant to traditional LAL methods

Learn about Jay Bolden and co-workers extensive study of peer-reviewed literature to find publications where naturally contaminated samples were tested side by side  (same samples, only difference being the test method, i.e. rFC vs LAL/TAL).

EP publishes Chapter 2.6.32 introducing rFC

With the publication of supplement 10.3, EP officially introduces recombinant Factor C as a compendial method.

From LAL to rFC assay

Explore the history of LAL endotoxin testing towards the development of the recombinant Factor C assay. The American horseshoe crab population is now a vulnerable species, just one step from being endangered. The rFC assay has gone a long way to be accepted but as there is a growing recognition of its importance by various Pharmacopeia, a widespread adoption of the rFC method could be on the horizon.

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