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Allergy Injections and Endotoxins

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Article overview

Endotoxin Testing for Cell and Gene Therapy Products

Cell and gene therapy are a hot topic, but are you aware of the requirements around endotoxin testing for these products? Here is a short overview. 

Comparing endotoxin testing results of modern recombinant to traditional LAL methods

Learn about Jay Bolden and co-workers extensive study of peer-reviewed literature to find publications where naturally contaminated samples were tested side by side  (same samples, only difference being the test method, i.e. rFC vs LAL/TAL).

Models for Safety Testing of Biopharmaceuticals

A novel T cell: PMBC assay to test for immunogenicity.

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References

  1. Allergy Immunotherapy” ACAAI Public Website, 14 Nov. 2018
  2. Trivedi, B., Valerio, C., and Slater, J. (2003) Endotoxin content of standardized allergen vaccines. Journal of Allergy and Clinical Immunology, 111(4), 777-783