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Human Liver-Derived Endothelial Cells P1

Human Liver-Derived Endothelial Cells P1

Catalog #: HLECP1
Low passage endothelial cells dervied from human liver tissue
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Product Overview

Endothelial cells are the primary barrier cells that line blood vessels and sinusoids of the liver. Human Liver-derived Endothelial Cells (HLECs) are isolated and enriched from liver tissue, then cryopreserved for use in a wide range of research models. A unique subtype of LECs, liver sinusoidal endothelial cells, are defined as a subset of cells found at the interface between the liver sinusoids and hepatocytes.

 

HLECs derived from whole livers lead to a mixed population of vascular endothelial cells and sinusoidal endothelial cells. HLECs characterized for markers of endothelial cells, including vWF maintain appropriate endothelial morphology over limited serial passaging. Measurement of uptake of acetylated LDL as well as CD32b to indicate percentage of the sinusoidal endothelial cell population. The recommended medium for HLECs is EGMTM 2 which is optimized for endothelial cell health and growth.

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Benefits

  • Low passage
  • Verified for large molecule uptake

Storage and Content

Cryopreserved Cells, >1 Million viable cells
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SDS, CoA, and Instructions

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

  • Instructions for Use - Hepatocyte and Non-Parenchymal Cell (NPC) 2D Co-Culture

    Protocol for 2D co-culture of human hepatocytes and non-parenchymal cells
  • Hepatocytes and Non-parenchymal Cells - Development and Optimization of a Comprehensive Co-Culture

    Tech Note detailing the development of a co-culture protocol for Heps and NPCs
  • 3D Spheroid Primary Human Hepatocyte and Non-Parenchymal Cell (NPC) Co-Culture - Instructions for use

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Educational Material

Brochures, White Papers etc.

  • Primary Human Hepatocyte 3D Spheroids Co-cultured with Non-Parenchymal Cells

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Build In Vivo-Relevant Liver Models by Adding Non-Parenchymal Cells

Hepatocyte Applications & Product Info

Learn how to create more complex liver models with hepatic non-parenchymal cells, including Kupffer cells, stellate cells, and liver sinusoidal endothelial cells.

Human Hepatocte Inventory

View donor information and select characteristics of currently available hepatocyte lots.

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