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Pharma & Biotech

DonorPlexTM Pooled Donor Human Hepatocytes, 50 Donor, Mixed Gender

Catalog #: HUCS50P
Pooled 50-donor, mixed-gender human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities. Ideal for drug metabolite identification, characterization, and turnover kinetics.
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Product Overview

A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm, we are able to predict yield, viability, and functional phenotype representing the average human populations.  The DonorPlexTM Pooled Donor Human Hepatocytes, 50 Donor, mixed-gender, is a roughly 50:50 (max 70:30) mixed gender, 50 donor pool designed to function like the average human liver.  Each batch is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.

With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs. 

DonorPlexTM Pooled Donor Human Hepatocytes, 50 Donor, mixed-gender hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays in a mixed gender pool.  These suspension qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.

Benefits

  • Targeted pooling method for predictable metabolism 
  • Precharacterized for 9 CYPs and 4 drug transporters
  • High viability and yields
  • Lot sizes < 2000 are possible

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

DonorPlexTM Pooled Donor Suspension Hepatocytes

Technical Note

Read our new tech note to learn more about DonorPlexTM Hepatocytes, our pooled donor hepatocytes, and a proprietary prediction algorithm,  go beyond your expectations for a robust and consistent pooled donor hepatocyte product.

Custom DonorPlexTM Human Hepatocytes Request

Form

Start your path towards obtaining DonorPlexTM Hepatocytes customized for your specific needs.

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