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Pharma & Biotech

DonorPlexTM Pooled Donor Human Hepatocytes, 20 Donor, Mixed Gender

Catalog #: HUCS20P
Pooled donor human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities
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Product Overview

A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm we are able to predict yield, viability, and functional phenotype of DonorPlexTM Human Hepatocytes which in turn will support more consistent results in your DMPK. Each batch of pooled 20-donor, mixed gender human hepatocytes is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.

With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs.

The DonorPlexTM Hepatocytes – Suspension Qualified hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays. The Suspension Qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.

Benefits

  • Targeted pooling method for predictable metabolism 
  • Precharacterized for 9 CYPs and 4 drug transporters
  • High viability and yields
  • Lot sizes < 2000 are possible

Applications

  • Suspension metabolism studies

Content & Storage

Content

1 x Cryopreserved ampule of Pooled, Suspension-Qualified Hepatocytes containing >5 million viable cells

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Webinar -Hepatocytes in the Drug Development Pipeline

Overview of how primary hepatocytes are used in drug development

Human Hepatocyte Inventory

Human

Inventory

View donor information and select characteristics of currently available human hepatocyte lots. Table includes single donor and pooled donor lots in either suspension or plateable formats

Be Among the First to Know

CellAlertTM Sign-up

Register to receive email alerts when fresh hepatocytes or when new lots of cryopreserved hepatocytes become available.

Hepatocytes in the Drug Development Pipeline

Webinar

Curious about the various uses for hepatocytes in the drug development pipeline? Get a comprehensive overview of various models that one may apply to hepatocytes from the very basic to complex.

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