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Pharma & Biotech

Stellate cells, human cryopreserved, passage 1

Catalog #: HUCLS
Human Cryopreserved Stellate cells derived from liver
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Product Overview

Stellate cells are a resident cell type of the liver primarily functioning to store retinoids. In response to liver damage, stellate cells rapidly lose the stored retinoids and differentiate into a proliferating fibroblast-like cell that begins depositing collagen matrix. This activity causes buildup of collagen in the liver eventually leading to cirrhosis.

Stellate cells can be isolated from liver tissue, enriched, and placed into cell culture. When placed into culture, stellate cells begin to immediately differentiate into the activated state.

Isolated and enriched stellate cells are cryopreserved as passage 0 (having never been cultured) and at passage 1.

Human Stellate Growth Medium is available to support optimal culture health and growth characteristics of stellate cells.

Characterization performed:

  • Post-thaw plating to observe characteristic stellate morphology.
  • Flow cytometry using antibodies for Vinculin, Vimentin, and α-SMA

Benefits

  • Low Passage
  • High activation potential

Applications

  • ADMETox
  • Liver Disease
  • NASH

Content & Storage

Content

Cryo Vial

100,000 cells/ vial

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Webinar -Hepatocytes in the Drug Development Pipeline

Overview of how primary hepatocytes are used in drug development

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