Platinum UltraPAK™ Bioprocess Containers

As a leading supplier of flexible packaging for industrial and research applications, Lonza uses high quality proprietary film for the construction of its Platinum UltraPAK^TM Products – a state-of-the-art packaging solution for cell culture media and related products.

In the rapidly developing cell therapy and bioprocessing fields, new processes and procedures are emerging that require the packaging of sterile liquid media and reagents in pre-made Flexible Bioprocess Containers. Lonza’s Platinum UltraPAK^TM Flexible Bioprocess Containers are single-use containers for liquid cell culture media, reagents, and buffers, as well as containment and storage vessels for intermediate and final products yielded from manufacturing processes.

Platinum UltraPAK^TM Film consists of a two-web design, with both layers made entirely of non-animal origin (NAO) material. These layers consist of an inner contact and an outer support layer, with the inner product contact layer composed of high-quality, low density polyethylene to provide flexibility and a full NAO environment. The outer film layer is composed of nylon and polyethylene, which provides strength and acts as an excellent gas transmission barrier between the product and the environment.

Lonza Platinum UltraPAK^TM Flexible Bioprocess Containers provide several distinct advantages over rigid wall packaging systems. In particular, Flexible Bioprocess Containers:

• Expand or collapse as liquid levels change, eliminating the need for sterilization of vent filters
• Provide a disposable primary product contact surface that, when emptied, can be compressed into a small size optimal for disposal
• Eliminate the need for validation of cleaning procedures common with multiple-use containers
• Provide true closed systems for the addition and removal of media and reagents, offering the highest level of confidence in sterility maintenance during use
• Are available in a wide variety of sizes with fill volumes between 50 mL and 10,000 L
• Feature fluid-handling tubing sets and connector systems that can be fully customized to support your specific applications
• Allow liquid packaging with minimal internal airspace, minimizing changes in reagent pH or oxidation.

Platinum UltraPAK^TM film structure and composition

An important component of our packaging is its proprietary polyethylene film formulation, specifically created by our engineers to provide durability and flexibility. Aside from having superior gas barrier properties, exhibiting undetectable endotoxin levels, and being certified as a USP Class VI material, our film is also entirely non-animal in origin. As a result, our film completely and reliably protects a wide variety of products that may come into contact with it, such as:

• Cell culture media
• Buffers
• Water for Injection (WFI)
• Final product yielded from downstream manufacturing processes

Standard UltraPAK^TM Flexible Bioprocess Container configurations

The list below describes the components on our premium pre-designed, made-to-order containers.

Pre-filled bags

Lonza also offers a selection of media pre-filled in UltraPack^TM Bags: