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Pharma & Biotech

Human Kupffer Cells, 0.5 Million

Catalog #: HLKC
Human Cryopreserved Kupffer Cells
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Product Overview

Kupffer cells are the resident macrophages in the liver and are part of the first line of defense against bacteria and toxins in the gut. Kupffer cells exhibit typical macrophage morphology and can be activated to produce inflammatory cytokines, growth factors and reactive oxygen species.

In vivo, prolonged activation of Kupffers are associated with many diseases of the liver including Non-alcoholic Fatty Liver Disease (NAFLD), Non Alcoholic Steato Hepatitis (NASH), and liver damage associated with certain bioactivated chemicals.

Human Cryopreserved Kupffer cells are isolated and enriched from dissociated human liver tissue and then cryopreserved as passage 0. Characterization of isolated Kupffer cells includes assessing morphology in plated format and evaluating functional responses to LPS stimulation.

Benefits

  • LPS Inducible
  • High activation potential
  • Naive primary cells - never has contacted plastic dish

Applications

  • ADMETox
  • Disease Research

Content & Storage

Content

  • Cryo Vial
  • >0.5 million cells/vial

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

The importance of cell-subtype selection in creation of a 3D liver fibrosis model

Data sheet detailing 3D liver fibrosis model in collaboration with Viskol

Hepatocyte and Related Product Information Request

Information or Quote Request

Request information or quote for hepatocytes, SilensomesTM  HLM, or NoSpin HepaRGTM cells and media here.

Engineering Culture Platforms to Mimic Liver Diseases

Webinar

Learn from Dr. Salman Khetani, University of Illinois at Chicago, how multiple liver cell-types including hepatocytes, Kupffer, stellate, and endothelial cells can be engineered together to model human liver disease phenotypes in culture.

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