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The Importance of In Vitro ADME and Toxicity Studies in Drug Discovery and Development

Understanding the absorption, distribution, metabolism, excretion (ADME), and toxicity (ADME-Tox) of new drugs is a key element of drug discovery. These studies provide insights into the disposition of a pharmaceutical compound in the body, including its safety and efficacy.

Obtaining in vitro ADME-Tox data as early as possible in the drug discovery process has many advantages. For example, the results generated from ADME-Tox studies early in development provide valuable indicators as to whether a compound will have good bioavailability, helping to avoid costly clinical stage failures when drug candidate don’t meet ADME properties or show early signs of being toxic.

One of the key challenges with interpretation of ADME-Tox studies in pre-clinical drug development is identifying the appropriate models that can provide clinically relevant results. While animal models remain one of the most important tools in preclinical ADME-Tox studies, in vitro systems such as culturing primary human cells are becoming increasingly important for decision making in the drug development pipeline.

Below, we outline the use of primary cells in ADME-Tox studies.

skin toxicity testing

Skin Toxicity Testing

Skin Cell Applications & Product Info

Explore publications, whitepapers and other supporting tools related to our keratinocytes, fibroblasts and 3D culture products for toxicity applications.

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Renal Absorption and Toxicity

Kidney Cell Applications & Product Info

Our collection of renal cells and growth media products along with an archive of publications and protocols guides researchers to utilize our products in understanding clinically relevant drug transporter functions.

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Respiratory Absorption

Lung Cell Applications & Product Info

Our broad collection of airway cells from normal and diseased donors along with growth and differentiation media have been utilized for decades to support various applications for respiratory research. Explore key publications, whitepapers and other supporting tools related to pulmonary absorption and toxicity applications.

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Cryopreserved Primary Neural Cells and Media

Neural Cells Applications & Product Info

Did you know Lonza offers a range of high-quality, ready-to-use, cryopreserved human, mouse and rat primary neuron and glial cells prepared from freshly isolated and dissociated embryonic or neonatal nervous tissue from Sprague Dawley rats or CD-1/C57 Black mice.

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Cell Proliferation and Cytotoxicity Assays

Cell Proliferation & Cytotoxicity Assays

Product Info

Assessing the growth and health of your cell cultures, including during compound screening, involves measuring viability and toxicity. Lonza offers three different highly sensitive assays that have been developed to safely and quickly assess the health of your 2D and 3D cell cultures.

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ADME & Toxicology Products

Pharmacokinetics and Bioactivation

Primary Hepatocytes

Human Hepatocytes - General Purpose

HUCPG

Human Hepatocytes - Interaction Qualified

HUCPI

Human Hepatocytes - Suspension Single Donor

HUCSD

DonorPlex^TMHuman Hepatocytes- Suspension 10 Donor

HUCS10P

DonorPlex^TM Human Hepatocytes- Suspension 20 Donor

HUCS20P

Cynomolgous Hepatocytes - Suspension

CYCS01-C

Cynomolgous Hepatocytes - Plateable

CYCP01-C

Mouse C57BL/6 Hepatocytes - Suspension

MBCS01

Mouse C57BL/6 Hepatocytes - Plateable

MBCP01

Mouse CD-1 Hepatocytes - Suspension

MCCS01

Mouse CD-1 Hepatocytes - Plateable

MCCP01

Rat (SD) Hepatocytes Suspension

RSCS01

Rat (SD) Hepatocytes Plateable

RSCP01

Rat (Wistar Hannover) Hepatocytes Suspension

RWCS01

Rat (Wistar Hannover) Hepatocytes Plateable

RWCP01

Rat (Wistar) Hepatocytes Suspension

RICS01

Rat (Wistar) Hepatocytes Plateable

RICP01

Dog (Beagle) Hepatocytes Suspension

DBCS01

Dog (Beagle) Hepatocytes Plateable

DBCP01

Human Liver Microsomes

Silensomes^TM CYP2C8 w/Control

SIL000

Silensomes^TM CYP1A2 w/Control

SIL200K

Silensomes^TM CYP2A6 w/Control

SIL210K

Silensomes^TM CYP2B6 w/Control

SIL220K

Silensomes^TM CYP2C9 w/Control

SIL230K

Silensomes^TM CYP2D6 w/Control

SIL240K

Silensomes^TM CYP3A4 w/Control

S IL250K

Silensomes^TM Master Control

SIL260K

Silensomes^TMCYP Phenotyping Kit

SIL-MCPNL

Hepatocyte Cell Lines

NoSpin HepaRG^® cells

NSHPRG

Kidney Cells

Cortical epithelial cells

CC-2554

Renal epithelial cells

CC-2556

Renal proximal tube epithelial cells

CC-2553

Absorption Modeling

Lung Cells

Bronchial/Tracheal epithelial cells with retinoic acid

CC-2547

Bronchial/Tracheal epithelial cells without retinoic acid

CC-2540

Small airway epithelial cells

CC-2541

Skin Cells

Adult dermal fibroblasts

CC-2511

Epidermal keratinocytes, Adult

CC-2509

Epidermal keratinocytes, Neonatal

192627

Epidermal keratinocytes, Neonatal pooled

192907

Neonatal dermal fibroblasts

192906

Mechanistic Toxicity

Nervous System Cells

Mouse Brain CD1 Hippocampus Neurons

R-CX-500

Mouse C57 Brain Cortex Neurons

M-CX-400

Mouse CD1 Brain Cortex Neurons

M-CX-300

Rat Brain Cortex Neurons

R-HI-501

Rat Brain Hippocampus Neurons

M-HI-401

Rat Microglia

R-G-535

Intestinal Cells

Intestinal epithelial cells

CC-2931

Liver Cells

Human and Animal Hepatocytes

(See Section 1)

Human liver NPCs cells 1e6

HUCNP

Human Stellates 1e5 per vial

HUCLS

Human Stellates 1e6 per vial

HUCLS1

Human Kupffer Cells

HLKC

Human Liver-Derived Endothelial Cells

HLECP2

Kidney Cells

Cortical epithelial cells

CC-2554

Renal epithelial cells

CC-2556

Renal proximal tube epithelial cells

CC-2553

Lung Cells

Human Airway Epithelial Cells

(See Section 2)

Bronchial smooth muscle cells

CC-2576

Lung microvascular endothelial cells

CC-2527

Skeletal Muscle Cells

Skeletal muscle cells

CC-2580

Skeletal muscle myoblasts

CC-2561

Vascular Cells

Aortic endothelial cells

CC-2535

Aortic smooth muscle cells

CC-2571

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In Vitro ADME-Tox Applications

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The Importance of In Vitro ADME and Toxicity Studies in Drug Discovery and Development

Applications for Primary Cells in ADME & Toxicology

Liver Cells for ADME & Toxicology Studies

Skin Toxicity Testing

Skin Cell Applications & Product Info

Renal Absorption and Toxicity

Kidney Cell Applications & Product Info

Respiratory Absorption

Lung Cell Applications & Product Info

Cryopreserved Primary Neural Cells and Media

Neural Cells Applications & Product Info

Cell Proliferation & Cytotoxicity Assays

Product Info