The Importance of In Vitro ADME and Toxicity Studies in Drug Discovery and Development

Find the appropriate format of hepatocytes for your drug metabolism study. 

Advancing pooled-donor hepatocytes to the next level of consistency, robustness, and customizability

Visit this page to determine what format of hepatocytes is best for your disease modeling efforts.

Our broad collection of airway cells from normal and diseased donors along with growth and differentiation media have been utilized for decades to support various applications for respiratory research. Explore key publications, whitepapers and other supporting tools related to pulmonary absorption and toxicity applications. 

Explore publications, whitepapers and other supporting tools related to our keratinocytes, fibroblasts and 3D culture products for toxicity applications.

Assessing the growth and health of your cell cultures, including during compound screening, involves measuring viability and toxicity. Lonza offers three different highly sensitive assays that have been developed to safely and quickly assess the health of  your 2D and 3D cell cultures. 

CYP phenotyping helps predict the impact of co-administered drugs on the pharmacokinetics of the new chemical entity. 

Our collection of renal cells and growth media products along with an archive of publications and protocols guides researchers to utilize our products in understanding clinically relevant drug transporter functions. 

Because of the many physiological processes that depend on the liver, a fundamental understanding of liver biology and the ability to address these at the benchtop is essential for researchers involved in creating new, life-saving medicines.

It was formerly believed that only freshly isolated hepatocytes would reflect the appropriate metabolism, but advancements in cryopreservation techniques now allow metabolic reactions to proceed following the recovery of cryopreserved cells.

 Learn more about the various formats of hepatocytes and their applications, including suspension, plated monolayer, sandwich culture, and spheroids.

Alternative hepatocyte models include tumor cell lines such as Huh-7 and HepG2 cells. Tumor cell lines include the advantage of self-renewal…

 The first step in lot selection should be to determine the duration of the assay and whether a plateable qualified lot is essential.

Lonza offers primary neural cells to support in vitro toxicity screening. Download Lonza and Axion Biosystems’ poster from the SOT 2019 conference discussing the use of primary cortical cell models and microelectrode array (MEA) technology for neurotoxicology and safety pharmacology assessment applications.

View our calendar of planned rodent isolations for the year.

View donor information and select characteristics of currently available hepatic cell lots.

Download our Technical Note showing the use of Lonza’s Keratinocytes, Fibroblasts and RAFT^TM 3D Culture System to create a Full Thickness Skin cell Model.