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Human Cryo Kupffer Cells, 0.2 Million

Human Cryo Kupffer Cells, 0.2 Million

Catalog #: HLKC-200K

Naïve Kupffer cells derived from human liver tissue. 0.2 million cells per vial

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 748.00 CHF
AMP

Product Overview

Kupffer cells are the resident macrophages in the liver and are part of the first line of defense against bacteria and toxins in the gut. Kupffer cells exhibit typical macrophage morphology and can be activated to produce inflammatory cytokines, growth factors and reactive oxygen species.

In vivo, prolonged activation of Kupffer cells are associated with many diseases of the liver including Non-alcoholic Fatty Liver Disease (NAFLD), Non Alcoholic Steato Hepatitis (NASH), and liver damage associated with certain bioactivated chemicals. Human Cryopreserved Kupffer cells are isolated and enriched from dissociated human liver tissue and then cryopreserved as passage 0. Characterization of isolated Kupffer cells includes assessing morphology in plated format and evaluating functional responses to LPS stimulation.

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Benefits

  • LPS Inducible
  • High activation potential
  • Naïve primary cells - never has contacted plastic dish

Applications

  • ADMETox
  • Disease research

Storage and Content

Cryopreserved Cells, > 200K viable cells
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SDS, CoA, and Instructions

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

  • Instructions - Cryopreserved Kupffer Cells

    Instructions for Thawing and Plating of Human Cryopreserved Kupffer Cells
  • Instructions for Use - Hepatocyte and Non-Parenchymal Cell (NPC) 2D Co-Culture

    Protocol for 2D co-culture of human hepatocytes and non-parenchymal cells
  • Hepatocytes KC Cell Co-Culture Protocol

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Educational Material

Brochures, White Papers etc.

  • Primary Human Hepatocyte 3D Spheroids Co-cultured with Non-Parenchymal Cells

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Build In Vivo-Relevant Liver Models by Adding Non-Parenchymal Cells

Hepatocyte Applications & Product Info

Learn how to create more complex liver models with hepatic non-parenchymal cells, including Kupffer cells, stellate cells, and liver sinusoidal endothelial cells.

Human Hepatocte Inventory

View donor information and select characteristics of currently available hepatocyte lots.

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