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Immuno-oncology Applications

One of the major goals of biologics and immuno-oncology research is to stimulate and promote a response via engagement of specific target(s) to impact and modulate the underlying cellular physiology. 
Our portfolio of integrated solutions of primary cells and optimized cell culture systems provides the backbone to build cellular models for preclinical research within biologics and immuno-oncology. Our cells and media are optimized to work with each other to guarantee consistent and reproducible results in biologically relevant human primary cell model systems.  

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Applications

Immuno-oncology Applications

An overview of immuno-oncology strategies

Some immune-oncology treatments work by enhancing the immune system, such as interleukins and Colony stimulating factors without targeting cancer cells directly. However, other novel immune-oncology treatment modalities have increased in complexity and specificity to include cell based administration of target specific TCR-engineered T cells, Chimeric antigen receptors (CARs), expanding tumor-infiltrating lymphocytes (TILs) cancer vaccines and other immune cells such as monocytes, macrophages and NK (natural killer) cells. Immuno-oncology treatments are being assessed in combination with a wide range of modalities to deliver maximal benefits for the patient.

Cell-based assays are critical in every stage of the biologics and immunotherapy development from early discovery, pre-clinical,
clinical and post launch population response analysis. 

They are utilized for: 

  • Lead candidate selection
  • Mode of action (MOA)  analysis
  • Safety, efficacy, Toxicity testing 
  • Off-target effects in a cellular environment 

Cell-based assays aka immunogenicity and immunotoxicity assays investigate the potency of immune-oncology therapies, either by enhancing interaction of cytotoxic cells with their tumor targets or by promoting cancer cell killing by overcoming T cell tolerance and increasing T cell or NK cell activation.

Peripheral Blood lymphocytes or specific isolated cell types such as T cells, Dendritic cells, NK cells can be used in immunogenicity assays such as:

Immunogenicity and immunotoxicity

Cell-based assays for immunogenicity and immunotoxicity
 

Cell tools
for humanized mice

Mice in which human cells (or genes, tissues, and organs) have been introduced
 

CellBio
Services

Supported by decades of cell isolation and transfection experience, Lonza has built an extensive catalog offering