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Pharma & Biotech

Bovine Brain Microvascular Endothelial Cells

Catalog #: AC-2509

Cryopreserved ampule of bMVEC-B, Bovine Brain Microvascular Endothelial Cells containing ≥ 750,000 cells.

 

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Product Overview

The Bovine Brain Microvascular Endothelial Cell System (bMVEC-B) is a model of the Blood Brain Barrier. The system is designed to significantly improve a researcher’s ability to study active and passive transport of drugs across the blood brain barrier, to study brain endothelial cell tight junctions, and to study the basic biology of brain microvascular endothelial cells.

The bMVEC System consists of cryopreserved primary bovine brain microvascular endothelial cells from a pool of multiple donor brains. The endothelial cells express cellular tight junctions (positive for the proteins ZO-1 and Claudin-1), and transport characteristics (P-Glycoprotein function) found in the blood brain barrier. Thus the system can be used in early stage ADME-Tox screening assays to demonstrate whether test compounds are likely to cross the blood brain barrier.

Recommended Media: EBM-2 Basal Medium, 500 mL (CC-3156)

Benefits

  • Ready-To-Use 
  • No tissue dissection or animal handling required 
  • Increased data reproducibility
  • Characteristic morphology and staining tests confirm tissue origin and cell type
  • Negative for mycoplasma, bacteria, yeast and fungi
  • Certificate of Analysis (CoA) is available for every batch 

Applications

  • Neurotoxicity
  • Drug/Compound Screening
  • Advanced Cell Culture Models
  • Neurotransmitter Function
  • Signaling Pathways

 

Content & Storage

Content

Cryopreserved ampule with ≥ 750,000 cells/vial

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

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