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Pharma & Biotech

Human Hepatocytes, Cryopreserved, Plateable and Induction Qualified

Catalog #: HUCPI

Cryopreserved Human Hepatocytes, Plateable, Induction Qualified are tested for induction of CYP1A2, 2B6, and 3A4 genes by measuring the fold change in mRNA expression and/or activity following treatment with known inducers.

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Product Overview

Cryopreserved Human Hepatocytes, Plateable, Induction Qualified are tested for induction of CYP1A2, 2B6, and 3A4 genes by measuring the fold change in mRNA expression and/or activity following treatment with known inducers. These hepatocytes are qualified for high viabilities and healthy cultures lasting a minimum of 5 days in culture. The Induction Qualified hepatocytes are ideal for studying drug-drug interaction potential and are prequalified to meet regulatory minimum guidances for cytochrome P450 mRNA and protein induction levels. They are also ideal for disease modeling, genomics applications, and other applications where high quality plated hepatocytes are required.

Benefits

  • Precharacterized for appropriate hepatocyte morphology
  • Large inventory of multiple donors
  • Precharacterized for basal and induced levels of CYP3A4, CYP2B6, and CYP1A2 that satisfy regulatory guidelines

Applications

  • Drug-Drug interaction studies
  • Low clearance metabolism studies
  • Disease modeling
  • Xenotransplantation
  • Short term cellular toxicity studies
  • 3D cell culture

Content & Storage

Content

Cryo Vial
>5 million viable cells

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Webinar -Hepatocytes in the Drug Development Pipeline

Overview of how primary hepatocytes are used in drug development

Human Hepatocyte Inventory

Human

Inventory

View donor information and select characteristics of currently available human hepatocyte lots. Table includes single donor and pooled donor lots in either suspension or plateable formats

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1+1=3: Buy two vials of cryopreserved hepatocytes, get the third free.

End of Year Promotion

For a limited time, buy 2 vials of cryopreserved primary human or animal hepatocytes and receive a 3rd vial for free. Terms and conditions apply.

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