Primary Cells for Humanized Mice
Humanized mice («humice») are mice in which human cells (or genes, tissues, and organs) have been introduced in order to represent a functional model that more closely resembles that of human biology. The use of humanized mice in critical disease research areas has been expanding significantly over the past decade, including
- Immuno-oncology
- Infectious Disease
- Transplantation research
- Graft vs host disease (GVHD)
- T cell modulation
Additionally humanized mice provide valuable models for safety testing including ADME/TOX and Immunogenicity impact.
Generating humanized mice
There are different types of humanized mice, each with specific relevance to a research application. Two of the most common and well used humanized mice are CD34 humanized mice and PBMC humanized mice. These models are generated by injecting human immune cells into an immune compromised mouse in order to reconstitue a functional human immune system.