TheraPRO^® CHO Media System

As the versatility and efficiency of antibody therapeutics continues to transform the healthcare industry, optimization of workflow and ease-of-use has become pivotal in accelerating time to market for new treatments.

The TheraPRO^® CHO Media System is a chemically defined, animal component-free formulation proven to optimize productivity and product quality when used in conjunction with the GS-CHO cell line, the prevalent protein expression system worldwide for therapeutic proteins and antibodies.

With speed-to-market in mind, the TheraPRO^® CHO Media System is scalable from cell line development through bioprocess manufacturing and supported by subject matter experts with extensive experience in troubleshooting production processes. All components of the system are manufactured in ISO 13485 certified facilities in accordance with GMP and are accompanied by a Drug Master File (DMF) and assistance with regulatory submissions.

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Why choose the TheraPRO^® CHO Media System?

The TheraPRO^® CHO Media System has been designed to be both scalable and easy to use. It has been specifically optimized for the CHOK1 GS-KO cell lines.

High production yield – Up to two times the protein titer production versus competing products., 4.5 g/L of protein and >90% cell viability.
High protein quality as proteins exhibits human-like glycosylation patterns
Scalable process – Increased process control from cell line development through manufacturing
Shorten time-to-market – Simplified processes reduce errors to get therapies to patients faster.
2-part production system – Easy to use, quick reconstitution protocol
Quality and expertise – All components are manufactured in accordance with GMP and in ISO 13485 certified facilities, ensuring quality and traceability, with extended support from Lonza’s subject matter experts

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Protein titer remains constant at different scales using the TheraPRO(R) CHO Media System

TheraPRO(R) CHO performance has been tested across a range of scales including 10 L, 50 L and 220 L. All scales show similar protein titer trends demonstrating TheraPRO(R) CHO is associated with high product quality across culture scales.

TheraPRO^® CHO Cloning Medium

Available in a convenient, ready-to-use 1X liquid solution
Can be used with a variety of common cloning methods for GS-CHO cells
Tested for pH, osmolality, endotoxin and sterility
Offered in 1 L bottles

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TheraPRO^® CHO Production Medium and Feed

Available as (1) medium and (1) feed in powder format
Supports high cell density culture of GS-CHO cells to yield exceptional quality protein product at maximal titers
Tested for pH, osmolality, endotoxin, bioburden, solubility, moisture, and component quantitative analysis
Offered in variety of sizes
Drug master file available

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