Large batches of hepatocytes from pooling donors together can supply research programs for many years. When a new batch of pooled donor human hepatocytes is needed, many researchers would like the new batch to be similar to the previous one.
We use a proprietary algorithm to predict final activity of a pooled donor batch prior to manufacture. Shown in Figure 2 are the results of the predicted activity of a 20-donor pool compared to the actual activity. This gives us the unique ability to work with customers to create lots with specific CYP activity, or produce lots with CYP levels that represent the average population.
With our optimized pooling procedure, we can provide our customers with a variety of pool demographics and sizes for their metabolism testing needs. With our predictive algorithm, we can also create customer-driven customizable pooled donor human hepatocyte lots to meet specific CYP activity requirements.