Product Overview

Peripheral blood CD8+ T cells, also referred to as cytotoxic T cells, are critical components of the adaptive immune response.  CD8 is a transmembrane glycoprotein which serves as a co-receptor for TCR (T Cell Receptor) to recognize antigens on major histocompatibility complex (MHC).  Once bound, CD8+ T cells kill the infected cell by secreting cytotoxic granules, containing granzymes and perforin, resulting in apoptosis of the target cell.

Cells You Can Count on to Perform

Lonza CD8+T Cells are isolated from peripheral blood of healthy donors using negative immunomagnetic separation. Cryopreserved CD8+ T cells are guaranteed ≥ 85% pure for CD8+ T cells, as assessed by flow cytometry. They are guaranteed to contain ≥ 10 million viable cells per vial. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased. Cells are available from multiple donors. Please contact Customer Service for details on available inventory and donor demographic characteristics (age, gender, and ethnicity).

Choices in Cell Type and Tissue Source

Hematopoietic and immune research requires cells from different donors and tissue sources. That's why Lonza offers many different peripheral blood cell types. If you need different cell types from the same donor, you can either isolate from Lonza cryopreserved PBMCs or contact Customer Service to inquire about cells matched from the same donor. 

Lonza guarantees the performance of Clonetics/Poietics cells only if appropriate Clonetics/Poietics media and reagents are used exlusively and the recommended storage and use protocols are followed. Any modifications made to the recommended cell systems including the use of alternative media, reagents or protocols, will void cell and media performance guarantees.  If you need assisstance in selecting the appropriate media, reagents, or protocol, please contact Lonza Scientific Support.