DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male
DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male
Pooled 10-donor, male human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities. Ideal for drug metabolite identification, characterization, and turnover kinetics.
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Product Overview
A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm we are able to predict yield, viability, and functional phenotype representing the average human populations. The DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male, is a single gender, 10 donor pool designed to function like the average male liver hepatocyte. Each batch of pooled 10-donor, male human hepatocytes is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.
With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs.
DonorPlexTM Pooled Donor Human Hepatocytes, 10 Donor, Male hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays in a single gender pool. The Suspension Qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.
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Benefits
- Targeted pooling method for predictable metabolism
- Precharacterized for 9 CYPs and 4 drug transporters
- High viability and yields
- Lot sizes < 2000 are possible
SDS, CoA, and Instructions
Safety Data Sheets (SDS)
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Certificate of Analysis (CoA)
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DonorPlex® Pooled Donor Suspension Hepatocytes
10-, 20-, and 50-donor single and mixed gender pools of hepatocytes and a proprietary prediction algorithm, DonorPlex® Hepatocytes go beyond your expectations for a robust and consistent pooled donor hepatocyte product. -
Instructions - DonorPlex™ Hepatocytes: Suspension Format
Instructions for proper use and culture of DonorPlex™ Suspension Hepatocytes
Educational Material
Brochures, White Papers etc.
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DonorPlex® Pooled Donor Suspension Hepatocytes
10-, 20-, and 50-donor single and mixed gender pools of hepatocytes and a proprietary prediction algorithm, DonorPlex® Hepatocytes go beyond your expectations for a robust and consistent pooled donor hepatocyte product. -
Instructions - DonorPlex™ Hepatocytes: Suspension Format
Instructions for proper use and culture of DonorPlex™ Suspension Hepatocytes