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Pharma & Biotech

NHDC – Human Dendritic Cells

Catalog #: CC-2701
NHDC cryo amp, ≥2.5 million cells
571.00 USD
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Product Overview

Dendritic Cells (DCs) act as the messenger cells of the immune system by processing antigens from pathogens and presenting the antigens to T cells to initiate an immune response. PoieticsTM Normal Human Dendritic Cells are tested for a panel of specific surface markers, including CD11c+, CD86+, CD80+. HLADR+, and CD14- to provide detailed characterization of the cells. These cells can survive up to 7 days in culture with the proper cytokines (IL-4 and GM-CSF) to maintain the cells as immature dendritic cells (iDCs). Cells can be further differentiated to mature dendritic cells with the addition of TNF-α and IL-1β. All dendritic cells are differentiated from peripheral blood monocytes isolated via Ficoll density gradient separation and are quality tested for optimal performance. Lonza's Normal Human Dendritic Cells would typically be classified as Mo-DC/MDDC (monocyte derived dendritic cells) or CD11c+ myeloid Dendritic Cells (DC). Applications: Antigen presentation and uptake Primary Research Pharmacology Drug-induced immunosuppression of cytokine secretion Cryopreserved PoieticsTM Normal Human Dendritic Cells (NHDC) are guaranteed to contain ≥3 million viable cells per ampoule. Expression levels are tested for CD80, CD86, HLA-DR, CD11c, and CD14 and provided for information only. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased. Recommended Medium: LGM-3TM Lymphocyte Growth Medium + 50 ng/ml GM-CSF + 50 ng/ml IL-4 Lonza guarantees the performance of CloneticsTM/PoieticsTM cells only if appropriate CloneticsTM/PoieticsTM media and reagents are used exclusively and the recommended storage and use protocols are followed. Any modifications made to the recommended cell systems including the use of alternative media, reagents or protocols, will void cell and media performance guarantees. If you need assistance in selecting the appropriate media, reagents, or protocol, please contact Lonza Scientific Support.

Content & Storage

Content

2.5 million cells/vial

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

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