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Pharma & Biotech

SAEC – Human Small Airway Epithelial Cells

Catalog #: CC-2547
SAEC, Small Airway Epithelial Cells
737.00 USD
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Product Overview

Lonza's Human Small Airway Epithelial Cells (SAEC) are isolated from normal human lung tissue the distal portion of the lung in the 1mm bronchiole area. 

Cryopreserved CloneticsTM SAECs are guaranteed through 15 population doublings and stain positive for cytokeratin 19.  SAECs labeled CC-2547S are suitable for air-liquid interface studies and areguaranteed for differentiation marked by cilia formation, mucin production, and TEER levels. All cells testnegative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B andhepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased.

Content & Storage

Content

1 x Cryopreserved Ampule with ≥500,000 cells/vial

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Co-culture Experiments with Lonza's Small Airway Epithelial Cells and SAGMTM BulletKitTM Media

Data Courtesy of Furukawa, et al. Lonza's SAEC cells were co-cultured with primary normal mammary epithelial cells, breast cancer cell lines MCF-7 and MDA-MB-231 in Lonza's SAGMTM BulletKitTM Growth Media. Breast cancer cell lines showed differences in morphology and proliferation rates in the presence of small airway epithelial cells. The image above shows phase contrast imaging with a fluorescent (red) overlay of MCF-7 cell line. MCF-7 cell lines survived as tight clusters in SAGMTM Media. When co-cultured with Lonza's primary SAECs, MCF-7 cells demonstrated enhanced growth all the while staying clustered.

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