3D cultures of HepaRG™ cells model physiologically relevant drug metabolism, drug-induced liver injury, and hepatic signaling pathways

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Originally recorded on 13 March 2018
at the Society of Toxicology Meeting in San Antonio, TX, USA.

In this online symposium, Dr. Stephen Ferguson, a leading researcher at the National Institute of Environmental Health Sciences (NIEHS), discusses the 3D culturing of HepaRG^TM Cells – a commonly used human hepatic cell line.

This webcast examines the development of organotypic in vitro liver models using HepaRG^TM Cells to improve the predictability of studies looking into drug metabolism, drug-induced liver injury, and hepatic signaling pathways.

Watch the video to learn how liver cells assembled in 3D spheroids, compared with 2D cultures, produced highly differentiated functionality and utility for toxicology screening.

Speakers

• Stephen Ferguson, PhD, Research Scientist, NIEHS
• Maureen Bunger, PhD, Product Manager, ADMETox Solutions Lonza