DonorPlexTM Pooled Donor Human Hepatocytes, 20 Donor, Mixed Gender
DonorPlexTM Pooled Donor Human Hepatocytes, 20 Donor, Mixed Gender
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Product Overview
A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm we are able to predict yield, viability, and functional phenotype of DonorPlexTM Human Hepatocytes which in turn will support more consistent results in your DMPK. Each batch of pooled 20-donor, mixed gender human hepatocytes is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.
With our large inventory of single donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs.
The DonorPlexTM Hepatocytes – Suspension Qualified hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays. The Suspension Qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.
Request More InfoBenefits
- Targeted pooling method for predictable metabolism
- Precharacterized for 9 CYPs and 4 drug transporters
- High viability and yields
- Lot sizes < 2000 are possible
Applications
- Suspension metabolism studies
Storage and Content
1 x Cryopreserved ampule of Pooled, Suspension-Qualified Hepatocytes containing >5 million viable cells
SDS, CoA, and Instructions
Safety Data Sheets (SDS)
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Certificate of Analysis (CoA)
Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.
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DonorPlex® Pooled Donor Suspension Hepatocytes
10-, 20-, and 50-donor single and mixed gender pools of hepatocytes and a proprietary prediction algorithm, DonorPlex® Hepatocytes go beyond your expectations for a robust and consistent pooled donor hepatocyte product. -
Instructions - DonorPlex™ Hepatocytes: Suspension Format
Instructions for proper use and culture of DonorPlex™ Suspension Hepatocytes
Educational Material
Brochures, White Papers etc.
Videos
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DonorPlex® Pooled Donor Suspension Hepatocytes
10-, 20-, and 50-donor single and mixed gender pools of hepatocytes and a proprietary prediction algorithm, DonorPlex® Hepatocytes go beyond your expectations for a robust and consistent pooled donor hepatocyte product. -
Instructions - DonorPlex™ Hepatocytes: Suspension Format
Instructions for proper use and culture of DonorPlex™ Suspension Hepatocytes -
Webinar - Hepatocytes in the Drug Development Pipeline
Overview of how primary hepatocytes are used in drug development
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Designed for Purpose – Complex Liver Cell Cultures for Improving In Vitro Hepatotoxicity Testing
Recording of SOT 2018 Symposium presented by Drs. Jessica Hartman and Martin Phillips. -
3D Cultures of HepaRG™ Cells Model Physiologically Relevant Drug Metabolism, Drug-Induced Liver Injury, and Hepatic Signaling Pathways
Recording of SOT 2018 Symposium presented by Dr. Stephen Ferguson. -
Hepatocytes in the Drug Development Pipeline
Webinar describing how hepatocytes are used in drug development delivered by Dr. Salman Khetani, Professor at University of Illinois, Chicago.