D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells – Asthma for B-ALI™ Culture
D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells – Asthma for B-ALI™ Culture
Product Overview
Asthma is an inflammatory disorder of the airways, which causes attacks of wheezing, shortness of breath, chest tightness, and coughing in patients. Degrees of severity are unique to individual patients as are responses to drug treatments. Adhesion of eosinophils to bronchial epithelial cells, and the interaction of airway smooth muscle and sub-epithelial fibroblasts play a critical role in asthma pathology. During an asthma attack bronchiole smooth muscle tissue can constrict and decrease the flow of air in the airways. The amount of air flow can further be decreased by inflammation or excess mucus secretion.
Cryopreserved Diseased Bronchial Epithelial cells test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased. Our catalog number 00194911S are suitable for air-liquid interface studies and are guaranteed to promote full differentiation of the airway epithelium expressed by the formation of a polarized epithelium with good barrier function (transepithelial resistance), secretory phenotype (mucin secretion) and ciliogenesis. Differentiation usually will occur by day 22 in culture.
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1 x Cryopreserved Ampule with ≥500,000 cells/vialSDS, CoA, and Instructions
Safety Data Sheets (SDS)
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Certificate of Analysis (CoA)
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Instructions - Airway Epithelial Cell Systems
Instructions for Proper Use and Culture of Airway Epithelial Cells -
Primary Cells and Media Reference Guide
A comprehensive collection of Lonza primary cell and media products supporting many research areas. -
Instructions - B-ALI™ Air-Liquid Interface Medium
Instructions for Proper Use and Culture
Educational Material
Brochures, White Papers etc.
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B-ALI Bronchial Air Liquid Interface Media Kit, a Guaranteed 3D in vitro Model for Respiratory Research
Lonza Whitepaper -
Primary Human Airway Cells and Media
Airway Cell and Media Reference Guide -
Gene Expression Differences in Airway Epithelial Cells from Asthma or COPD Donors
Access to diseased primary cells from patients diagnosed with COPD or asthma provides a convenient, biologically relevant model to assess genetic and in some cases phenotypic changes from normal, healthy donor tissues. In this study, we grew human bronchial epithelial (HBE) cells from normal, COPD-, and asthma-diagnosed human donor lung tissues in an air-liquid interface (ALI) model to assess potential phenotypic changes in vitro as well as provide a differentiated layer of cells to harvest for gene expression studies using the StellARray™ Gene Expression System. -
Primary Cells and Media Reference Guide
A comprehensive collection of Lonza primary cell and media products supporting many research areas. -
Primary Cells for Airway Research – Infographic
Infographic showing how Lonza primary cells can aide in your airway research