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D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells – Asthma

D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells – Asthma

Catalog #: 00194911
D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells from donors having Asthma
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Product Overview

Lonza's Asthmatic Airway Cells include lung fibroblasts, bronchial epithelial and bronchial smooth muscle cells. Bronchial epithelial cells are isolated from epithelial lining of airways above bifurcation of the lungs.

Asthma is an inflammatory disorder of the airways, which causes attacks of wheezing, shortness of breath, chest tightness, and coughing in patients. Degrees of severity are unique to individual patients as are responses to drug treatments. Adhesion of eosinophils to bronchial epithelial cells, and the interaction of airway smooth muscle and sub-epithelial fibroblasts play a critical role in asthma pathology. During an asthma attack bronchiole smooth muscle tissue can constrict and decrease the flow of air in the airways. The amount of air flow can further be decreased by inflammation or excess mucus secretion.

Cryopreserved Diseased Bronchial Epithelial cells from asthma donors test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased. Our catalog number 00194911S are suitable for air-liquid interface studies and are guaranteed to promote full differentiation of the airway epithelium expressed by the formation of a polarized epithelium with good barrier function (transepithelial resistance), secretory phenotype (mucin secretion) and ciliogenesis. Differentiation usually will occur by day 22 in culture.

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Benefits

  • Test negative for mycoplasma, bacteria, yeast, and fungi
  • HIV-1, Hepatitis B and Hepatitis C are not detected for all donors and/or cell lots
  • A Certificate ofAnalysis is provided for each cell lot purchased

 

Applications

  • Gene expression pathways   
  • Phenotypic changes to compounds   
  • Transfect diseased cells   
  • Co-culture with immune cells   
  • Airway remodeling studies   
  • Cellular interactions 

 

Storage and Content

1 x Cryopreserved ampule of D-HBE-As containing ≥500,000 cells

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SDS, CoA, and Instructions

Certificate of Analysis (CoA)

Please enter Lot Number, including all zeros, located on the product label and please take into account that it is case sensitive.

  • Instructions - Airway Epithelial Cell Systems

    Instructions for Proper Use and Culture of Airway Epithelial Cells
  • TechSheet - Bronchial, Tracheal Epithelial Cell Systems

    Technical information sheet for Clonetics™ Bronchial and Tracheal cells
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Educational Material

Brochures, White Papers etc.

  • Comparison of Normal and Asthmatic Bronchial Epithelial Cells and Smooth Muscle Cells in Monolayer and RAFT™ 3D Cell Culture System

    Understanding the differences between normal and diseased lung cells in 2D vs 3D culture.
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