ADME & Toxicology Research Tools

Let Lonza be your main partner when developing new, innovative, in vitro ADME-Tox testing tools. With decades of experience and one-on-one support, we offer a large selection of high quality primary cells that more accurately represent tissue specific cell phenotypes. With that we’ll help you realize your vision for more clinically predictive in vitro tools as the future foundation for development of new, innovative drugs.

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Products for In Vitro DMPK

Using Primary Hepatocytes for Characterization of Drug Metabolism

Hepatocyte Applications & Product Info

Find the appropriate format of hepatocytes for your drug metabolism study.

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Cryopreserved Primary Neural Cells and Media

Neural Cells Applications & Product Info

Did you know Lonza offers a range of high-quality, ready-to-use, cryopreserved human, mouse and rat primary neuron and glial cells prepared from freshly isolated and dissociated embryonic or neonatal nervous tissue from Sprague Dawley rats or CD-1/C57 Black mice.

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CYP Phenotyping Studies Using Silensomes Human Liver Microsomes

Product Info

CYP phenotyping helps predict the impact of co-administered drugs on the pharmacokinetics of the new chemical entity.

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Renal Absorption and Toxicity

Kidney Cell Applications & Product Info

Our collection of renal cells and growth media products along with an archive of publications and protocols guides researchers to utilize our products in understanding clinically relevant drug transporter functions.

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ADME-Tox Knowledge Center

Related Products, Applications, Technical Resources

Access a number of resources to learn how our extensive portfolio of ADME-Tox tools can be used to advance your in vitro research.

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Products for In Vitro Toxicology

Using Primary Human Hepatocytes and Liver Non-Parenchymals for Drug and Chemical Toxicity Studies

Hepatocyte Applications & Product Info

Learn what format of hepatocytes or liver non-parenchymals is right for your toxicity applications.

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skin toxicity testing

Skin Toxicity Testing

Skin Cell Applications & Product Info

Explore publications, whitepapers and other supporting tools related to our keratinocytes, fibroblasts and 3D culture products for toxicity applications.

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Respiratory Absorption

Lung Cell Applications & Product Info

Our broad collection of airway cells from normal and diseased donors along with growth and differentiation media have been utilized for decades to support various applications for respiratory research. Explore key publications, whitepapers and other supporting tools related to pulmonary absorption and toxicity applications.

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quasi vivo 3d cell culture system

Advanced Culture Techniques for Liver Cells Types

3D Culture Applications & Product Info

3D liver cell culture models provide more physiologically relevant research results.

Cell Proliferation & Cytotoxicity Assays

Product Info

Assessing the growth and health of your cell cultures, including during compound screening, involves measuring viability and toxicity. Lonza offers three different highly sensitive assays that have been developed to safely and quickly assess the health of your 2D and 3D cell cultures.

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Guide to spheroid formation using Verified for Spheroids™ Human Hepatocytes

Tech Note

Use this protocol for spheroid formation with our Verified for Spheroids^TM Human Hepatocytes to support your next steps towards more physiologically relevant liver cell culture systems.

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ADME &Toxicology Products

Pharmacokinetics and Bioactivation

Primary Hepatocytes

Human Hepatocytes - General Purpose

HUCPG

Human Hepatocytes - Interaction Qualified

HUCPI

Human Hepatocytes - Suspension Single Donor

HUCSD

DonorPlex™Human Hepatocytes- Suspension 10 Donor

HUCS10P

DonorPlex™ Human Hepatocytes- Suspension 20 Donor

HUCS20P

Cynomolgous Hepatocytes - Suspension

CYCS01-C

Cynomolgous Hepatocytes - Plateable

CYCP01-C

Mouse C57BL/6 Hepatocytes - Suspension

MBCS01

Mouse C57BL/6 Hepatocytes - Plateable

MBCP01

Mouse CD-1 Hepatocytes - Suspension

MCCS01

Mouse CD-1 Hepatocytes - Plateable

MCCP01

Rat (SD) Hepatocytes Suspension

RSCS01

Rat (SD) Hepatocytes Plateable

RSCP01

Rat (Wistar Hannover) Hepatocytes Suspension

RWCS01

Rat (Wistar Hannover) Hepatocytes Plateable

RWCP01

Rat (Wistar) Hepatocytes Suspension

RICS01

Rat (Wistar) Hepatocytes Plateable

RICP01

Dog (Beagle) Hepatocytes Suspension

DBCS01

Dog (Beagle) Hepatocytes Plateable

DBCP01

Human Liver Microsomes

Silensomes™ CYP2C8 w/Control

SIL000

Silensomes™ CYP1A2 w/Control

SIL200K

Silensomes™ CYP2A6 w/Control

SIL210K

Silensomes™ CYP2B6 w/Control

SIL220K

Silensomes™ CYP2C9 w/Control

SIL230K

Silensomes™ CYP2D6 w/Control

SIL240K

Silensomes™ CYP3A4 w/Control

S IL250K

Silensomes™ Master Control

SIL260K

Silensomes™CYP Phenotyping Kit

SIL-MCPNL

Hepatocyte Cell Lines

NoSpin HepaRG® cells

NSHPRG

Kidney Cells

Cortical epithelial cells

CC-2554

Renal epithelial cells

CC-2556

Renal proximal tube epithelial cells

CC-2553

Absorption Modeling

Lung Cells

Bronchial/Tracheal epithelial cells with retinoic acid

CC-2547

Bronchial/Tracheal epithelial cells without retinoic acid

CC-2540

Small airway epithelial cells

CC-2541

Skin Cells

Adult dermal fibroblasts

CC-2511

Epidermal keratinocytes, Adult

CC-2509

Epidermal keratinocytes, Neonatal

192627

Epidermal keratinocytes, Neonatal pooled

192907

Neonatal dermal fibroblasts

192906

Mechanistic Toxicity

Nervous System Cells

Mouse Brain CD1 Hippocampus Neurons

R-CX-500

Mouse C57 Brain Cortex Neurons

M-CX-400

Mouse CD1 Brain Cortex Neurons

M-CX-300

Rat Brain Cortex Neurons

R-HI-501

Rat Brain Hippocampus Neurons

M-HI-401

Rat Microglia

R-G-535

Intestinal Cells

Intestinal epithelial cells

CC-2931

Liver Cells

Human and Animal Hepatocytes

(See Section 1)

Human liver NPCs cells 1e6

HUCNP

Human Stellates 1e5 per vial

HUCLS

Human Stellates 1e6 per vial

HUCLS1

Human Kupffer Cells

HLKC

Human Liver-Derived Endothelial Cells

HLECP2

Kidney Cells

Cortical epithelial cells

CC-2554

Renal epithelial cells

CC-2556

Renal proximal tube epithelial cells

CC-2553

Lung Cells

Human Airway Epithelial Cells

(See Section 2)

Bronchial smooth muscle cells

CC-2576

Lung microvascular endothelial cells

CC-2527

Skeletal Muscle Cells

Skeletal muscle cells

CC-2580

Skeletal muscle myoblasts

CC-2561

Vascular Cells

Aortic endothelial cells

CC-2535

Aortic smooth muscle cells

CC-2571

the next step in ADME-Tox…

the next step in ADME-Tox…

the next step in ADME-Tox…We’ll take it together.

Products for In Vitro DMPK

Using Primary Hepatocytes for Characterization of Drug Metabolism

Hepatocyte Applications & Product Info

Cryopreserved Primary Neural Cells and Media

Neural Cells Applications & Product Info

CYP Phenotyping Studies Using Silensomes Human Liver Microsomes

Product Info

Renal Absorption and Toxicity

Kidney Cell Applications & Product Info

ADME-Tox Knowledge Center

Products for In Vitro Toxicology

Using Primary Human Hepatocytes and Liver Non-Parenchymals for Drug and Chemical Toxicity Studies

Hepatocyte Applications & Product Info

Skin Toxicity Testing

Skin Cell Applications & Product Info

Respiratory Absorption

Lung Cell Applications & Product Info

Advanced Culture Techniques for Liver Cells Types

3D Culture Applications & Product Info

Cell Proliferation & Cytotoxicity Assays

Product Info

Guide to spheroid formation using Verified for Spheroids™ Human Hepatocytes