Undirected migration or chemokinesis is the non-oriented or random movement of a cell to a chemical stimulus. Changes in random movement involve an increase or decrease of speed, as well as alterations of amplitude or frequency of motile character. Chemokinesis plays an important role in certain pathophysiological conditions.
For example, undirected migration of natural killer (NK) cells induced by elevated concentrations of leptin is believed to cause impaired cytotoxicity of natural killer (NK) cells in obese individuals1. As NK cells are a key component of the innate immune system and the first defense against malignant cancers, undirected migration can have significant health implications. This could explain why obese individuals are more likely to develop various types of cancer such as hepatic and colon cancer2. Using assays to identify undirected cell migration is therefore important in disease research, which could inform the development of novel therapeutic targets.