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Boosting the Immune system
Steps to Take for Successful Substrate Delivery
Optimizing the immune system using novel genome editing techniques provides new tools to treat a broad range of diseases such as leukemia, solid-tumors or HIV.
For this purpose, substrate delivery into hematopoietic and blood cells is essential. This article covers the topics transfection efficiency and cell viability combined with preservation of functionality for various immune cell types, focusing on the NucleofectorTM Technology as transfection method…
Rising Global Need for Treatment of Inflammatory Bowel Disease: Cytokine Blocking Immunotherapies Show Potential
Inflammatory Bowel Disease (IBD) is an autoimmune disorder that causes chronic inflammation throughout all or part of a person’s gastrointestinal tract.
The role of immune cells in the inflammation pathway has been a new target for IBD therapies in recent years. Cytokine blocking compounds have been developed and are already showing success in blocking the immune response…
The number of people worldwide suffering from some form of allergy is extremely high. For some of these allergy sufferers, allergen specific immunotherapy (allergen-SIT) has provided more than temporary relief.
The immunological mechanism of allergen-SIT is essentially the induction of persistent specific allergen tolerance. The allergen-specific memory T and B cell responses are altered, leading to immune tolerance.
Chimeric antigen receptor-redirected T cells (CAR-T cells) have become a promising tool in the treatment of hematopoietic malignancies as well as solid tumors.
CARs expressed on T cells target surface antigens in their native conformation, independent of the major histocompatibility complex. In CAR-T cell therapies the collection of patient’s T cells is followed by…
This infographic outlines several characteristics of Natural Killer (NK) cells such as frequency in peripheral blood, defined subsets, the "missing self" hypothesis, and NK cells' use in current research.
Find out about differentiation, isolation, characterization and passages of Mesenchymal Stem Cells (MSCs) and their potential uses in regenerative medicine and cancer immunotherapy in this infographic.
PBMCs are a mixed population of myeloid and lymphoid cells. The myeloid cells include monocytes, dendritic cells, and macrophages. Monocytes circulate through the blood to different tissues, where they differentiate into tissue-resident macrophages and dendritic cells.
Macrophages are the Pac-Man cells of the immune system that engulf and destroy foreign substances and cancerous cells. There are resident macrophages that maintain a steady-state of general tissue repair. In addition, there are also…
Bone marrow and peripheral blood-derived HSCs allow for large numbers of CD34+ cells to be harvested and transplanted, but they are of limited utility if an HLA-matched donor is unavailable. Cord blood-derived hematopoietic stem cells offer a potential solution, as the cells tend to be more naïve, which may lead to fewer occurrences of host-versus-graft-disease (GVHD) in instances of HLA-mismatch.
Despite their potential in combating GVHD, cord blood-derived HSCs also pose a major challenge due to the limited number of cells available from…
Lonza has sponsored a poster, published by Nature Reviews Drug Discovery, which shows an overview of the different ways to design and generate CAR T cells and the journey to FDA approval in 2017. Download the free poster as a high-resolution PDF, and request your own print copy to display in your lab.
Lonza has sponsored a poster, published by Nature Reviews Drug Discovery, which discusses therapeutic approaches to enhance natural killer cell cytotoxicity. Download the free poster as a high-resolution PDF, and request your own print copy to display in your lab.