text.skipToContent text.skipToNavigation
Pharma & Biotech

Human Hepatocytes, Cryopreserved, Plateable and Induction Qualified

Catalog #: HUCPI

Cryopreserved Human Hepatocytes, Plateable and Induction Qualified are tested for induction of CYP1A2, 2B6, 2C8, and 3A4 genes by measuring the fold change in mRNA expression and/or activity following treatment with known inducers.  Each ampule contains >5 million cells. 

 

Compare
AMP

Product Overview

Cryopreserved Human Hepatocytes, Plateable and Induction Qualified are tested for induction of CYP1A2, 2B6, 2C8, and 3A4 genes by measuring the fold change in mRNA expression and/or activity following treatment with known inducers.

These hepatocytes are qualified for high viabilities and healthy cultures lasting a minimum of 5 days in culture. 

The Induction Qualified hepatocytes are ideal for studying drug-drug interaction potential and are prequalified to meet regulatory minimum guidances for cytochrome P450 mRNA and protein induction levels. They are also ideal for disease modeling, genomics applications, and other applications where high quality plated hepatocytes are required.

NEW!!

The Cryopreserved Human Hepatocytes, Plateable and Induction Qualified hepatocytes are now verified for long-term plating, plating in 96-well format, and for spheroid fomation capacity.   Please download our recent inventory from the link below and look for our new Verified for Long TermTM, Verified for 96-wellTM and Verified for SpheroidsTM Characteristics to select your optimal batch.

Benefits

  • Precharacterized for appropriate hepatocyte morphology
  • Large inventory of multiple donors
  • Precharacterized for basal and induced levels of CYP3A4, CYP2B6, and CYP1A2 that satisfy regulatory guidelines
  • Tested for Spheroid formation, Long-term culture, and 96-well plating 

Applications

  • Drug-Drug interaction studies
  • Low clearance metabolism studies
  • Disease modeling
  • Xenotransplantation
  • Short term cellular toxicity studies
  • 3D cell culture

Content & Storage

Content

Cryopreserved ampule of HUCPI containing >5 million viable cells

Instructions

Safety Data Sheets (SDS)

Certificate of Analysis (CoA)

Webinar -Hepatocytes in the Drug Development Pipeline

Overview of how primary hepatocytes are used in drug development

Human Hepatocyte Inventory

Human

Inventory

View donor information and select characteristics of currently available human hepatocyte lots. Table includes single donor and pooled donor lots in either suspension or plateable formats

Introducing...DonorPlexTM Pooled Donor Human Hepatocytes

Product Info

Advancing pooled-donor hepatocytes to the next level of consistency, robustness, and customizability

Guide to spheroid formation using Verified for SpheroidsTM Human Hepatocytes

Tech Note

Use this protocol for spheroid formation with our Verified for SpheroidsTM Human Hepatocytes to support your next steps towards more physiologically relevant liver cell culture systems.

We use cookies to deliver the best service to you. By continuing to browse the site, you are agreeing to our use of cookies.Ok